Adrenal Stress Profile
Your stress hormone pattern.

The Adrenal Stress Profile is a saliva-based test that measures cortisol and DHEA-S four times throughout the day — upon waking, at noon, in the late afternoon and at bedtime. It maps the diurnal rhythm of the HPA-axis (hypothalamus-pituitary-adrenal) and reveals dysfunction patterns that a single blood test cannot detect. The test differentiates between hypercortisolism (too high), hypocortisolism (adrenal fatigue) and dysregulated patterns (elevated at the wrong time of day).

Serum cortisol measured at a single time point gives a static value without diurnal context. HPA-axis function is assessed clinically via the diurnal rhythm pattern — not via a single value. Cortisol normally varies 10-fold throughout the day. Salivary cortisol at four time points provides the clinically meaningful diurnal curve and reveals whether the morning peak is insufficient, whether evening levels are too high, or whether the diurnal rhythm is inverted.

The kit is shipped home with four saliva collection tubes and detailed instructions. Samples are collected upon waking (immediately on waking, before eating or drinking), at noon, in the late afternoon and at bedtime. Each sample requires 1–2 ml of saliva. All samples are refrigerated and sent together to the laboratory.

The Adrenal Stress Profile is indicated for chronic fatigue, ME/CFS, insomnia, early morning waking, anxiety, low stress tolerance, recurrent infections, unexplained weight gain and autoimmune conditions — all conditions where HPA-axis dysregulation may be an underlying or contributing factor. It is particularly valuable when standard blood tests have returned normal results.