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MediBalans›Genova Diagnostics›Hormonal Panels
Genova Diagnostics · Hormones
Oestrogen Metabolites · Cortisol · Melatonin · HPA Axis

Genova Hormonal Panels
What blood hormones don't show.

Standard hormone blood tests measure circulating oestradiol, testosterone and cortisol at a single moment. They tell you how much hormone is present — not what your body does with it. Genova's urine-based hormonal panels measure metabolites, circadian rhythms and oestrogen processing pathways that blood testing fundamentally cannot capture.

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7+Hormonal panel options
Urine + SalivaHome collection
SNPsOptional genetic add-ons
Panel Overview

Genova hormonal panels — choose the right one

Comprehensive · First-line

Women's Health+

Hormones + organic acids + optional SNPs (CYP1B1, COMT, MTHFR, CYP1A1, Apo E). Saliva + urine. A single specimen gives a 360° picture of endocrine and metabolic status — the most comprehensive first-line hormonal investigation available.

Oestrogen metabolites — 2-OH, 4-OH, 16-OH
Cortisol curve (4 timepoints)
Melatonin, testosterone, DHEA
Organic acids — neurotransmitter metabolism
Targeted · Follow-up

Endo+ (Modular)

Build your own hormonal panel. Choose from: salivary hormones, serum hormones, urinary oestrogens, thyroid, adrenocortex and melatonin modules — customised to the clinical question. Best for targeted follow-up after initial mapping.

HPA Axis · Fatigue

Adrenocortex Stress Profile

Four timed saliva samples mapping cortisol and DHEA across the day. Cortisol Awakening Response (CAR) add-on available. The dedicated tool for HPA axis assessment — fatigue, burnout, chronic stress. Results show whether the adrenal response pattern is appropriate or dysregulated.

Premenopausal · Cycle Mapping

Rhythm Plus™

28-day saliva analysis mapping oestradiol and progesterone daily across the entire menstrual cycle. Includes adrenocortex stress profile and melatonin. Designed for premenopausal and perimenopausal women not on hormone supplementation.

Menopausal · Comprehensive

Menopause Plus™

Comprehensive salivary panel for peri- and post-menopausal women. Oestrogen, progesterone, testosterone, DHEA, cortisol and melatonin. Results referenced against supplemented and non-supplemented menopausal cohorts.

Oestrogen Risk · Targeted

Estrogen Metabolism Assessment

Urinary oestrogen metabolite profile — 2-OH-E1 (protective), 4-OH-E1 (genotoxic), 16-OH-E1 (proliferative) and the 2:16 ratio. The most targeted panel for oestrogen-dependent disease risk. Optional SNPs: CYP1B1, COMT.

The Science

Why oestrogen metabolites matter

Standard blood oestrogen tests measure total circulating oestradiol at a single timepoint. They reveal nothing about what the body does with that oestradiol — which metabolic pathways process it and whether the resulting metabolites are protective or harmful.

2-OH-oestrone (2-OH-E1) — the protective pathway, methylated by COMT to the inert 2-methoxy form.

4-OH-oestrone (4-OH-E1) — genotoxic. Forms DNA adducts. Elevated with CYP1B1 activation and COMT insufficiency.

16-OH-oestrone (16-OH-E1) — proliferative. Strongly oestrogenic. Elevated with insulin resistance and environmental toxin exposure.

The 2:16-OH-E1 ratio is a validated risk modifier for oestrogen-dependent conditions. Understanding which pathway dominates informs both risk stratification and therapeutic intervention.

GCR Integration at MediBalans

Three-layer oestrogen analysis

Oestrogen metabolite results from Women's Health+ or Estrogen Metabolism Assessment are cross-referenced with MethylDetox COMT genotype and GI Effects beta-glucuronidase activity — the two most important upstream drivers of oestrogen metabolite accumulation. This three-layer integration provides a complete picture of oestrogen biology that no single test can deliver.

MediBalans Proprietary

MethylDetox 38-gene panel

Covers COMT Val158Met (oestrogen methylation efficiency), CYP1B1 (oestrogen hydroxylation), MTHFR and 35 additional methylation and detoxification genes. Defines the genetic ceiling for oestrogen metabolism — mandatory before hormone therapy in complex cases.

Questions

Genova hormonal panels explained

Standard oestrogen blood tests measure total circulating oestradiol — they reveal nothing about what the body does with that oestradiol. The 2-OH-E1 pathway is protective; the 4-OH-E1 pathway is genotoxic (forms DNA adducts); the 16-OH-E1 pathway is proliferative. These metabolites determine oestrogen-dependent disease risk. Women's Health+ and the Estrogen Metabolism Assessment measure them directly — data that standard blood oestrogen testing cannot provide.

Women's Health+ is an integrated panel with hormones, organic acids and optional SNPs in a single specimen — designed for comprehensive first-line mapping. Endo+ is modular — the clinician selects which compartments to analyse. Endo+ is better suited for targeted follow-up; Women's Health+ for initial investigation.

No. DUTCH Complete is manufactured by Precision Analytical — a separate company. Genova Diagnostics has its own distinct hormonal panels: Women's Health+, Endo+, Rhythm Plus, Menopause Plus, Adrenocortex Stress Profile and Estrogen Metabolism Assessment. MediBalans works with Genova's panels as the official Swedish distributor.

CAR is the rapid cortisol peak occurring 30–45 minutes after waking — a distinct physiological response separate from the rest of the daily cortisol curve. A blunted or absent CAR indicates HPA axis dysregulation and predicts treatment-resistant fatigue, burnout and immune dysfunction. It can be added as an add-on to the Adrenocortex Stress Profile, Rhythm Plus and Menopause Plus panels.

Yes. Women's Health+, Adrenocortex Stress Profile, Rhythm Plus and Menopause Plus all use saliva and/or urine collection — home-based specimens that can be shipped internationally. The Estrogen Metabolism Assessment is also urine-based. The initial consultation and results review are conducted via video call in English.

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Overview

All Genova Tests

Full overview of Genova Diagnostics panels available via MediBalans — Sweden's official distributor.
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Map your hormonal health completely.

Book a consultation to determine which Genova hormonal panel is appropriate for your clinical picture. We handle ordering, interpretation and treatment.

Book Consultation → All Genova Tests
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