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Precision Medicine · Regenerative Research · Patent Portfolio

Research that
transforms the clinic

MediBalans conducts clinical research with direct application in patient care. Our work on Global Constraint Rule, biological age measurement and regenerative therapies is translated into protocols used at the clinic today — not in ten years.

7 Patent
3 Research Domains
42K Biomarkers (BioAge™)
Unifying Principle

Global Constraint Rule

The scientific foundation unifying MediBalans patent portfolio and clinical methodology.

Global Constraint Rule (GCR) is a systems biology principle describing how biological systems — from individual cells to entire organs — always operate under prevailing constraints. When a constraint is severe enough, the entire system reconfigures to compensate.

The clinical problem is that the visible dysfunction is rarely the primary constraint. Conventional medicine often treats the secondary compensation — and wonders why the effect is absent or recurs.

The GCR framework guides MediBalans diagnostics: we systematically search for the biological root constraint driving a condition, regardless of where it manifests clinically. This is the principle behind why the same symptom can require entirely different treatment in different patients.

Seven patents have so far emerged from this framework — in longevity medicine, regenerative therapies and precision nutrition.

Global Constraint Rule · Core Definition

Biological systems always adapt to their most limiting factor — not their most obvious one.

Identifying and correcting the root constraint is more effective than treating the adaptive compensations it has generated.

The same symptom can have fundamentally different biological origins
Treating compensations gives temporary effect — treating the constraint gives lasting results
Multi-omics diagnostics can identify the constraint with high precision
Protocol design must be adapted to the individual's specific constraint profile
Intellectual Property

7 Patent inom precisionsmedicin

The patent portfolio spans longevity medicine, regenerative therapies and precision nutrition — all unified by the Global Constraint Rule principle.

Patent 01 · Longevity
Biological Age Determination via RNA Transcriptome Analysis
Method for measuring biological age at cellular level through gene expression profiling against validated longevity biomarkers.
MediBalans BioAge™
Patent 02 · Regenerative
Translational Gap Analysis for Proteomic Intervention
Patented method for identifying the discrepancy between gene expression and protein production — the translational gap driving cellular dysfunction.
Proteomics
Patent 03 · Precision Nutrition
Intracellular Micronutrient Mapping for Protocol Design
System for translating intracellular nutritional status (55 micronutrients) into personalised supplementation protocols via GCR ranking.
CMA · Nutrition
Patent 04 · Immunology
Dynamic Immune Reactivity Profile for Elimination Protocols
Method for time-series measurement of immune reactivity to food antigens and translating change patterns into adaptive elimination and reintroduction protocols.
ALCAT · Immunology
Patent 05 · Methylation
Methylation Capacity Index for Regenerative Treatment Planning
Algorithm integrating SNP profile, biomarker data and clinical anamnesis into a composite methylation capacity index with direct protocol implications.
MethylDetox · Epigenetics
Patent 06 · Neurology
Autonomic Regulation via HRV Biofeedback and Cellular Nutrition
Combination protocol integrating HRV measurement with cellular nutritional status to optimise autonomic nerve regulation and mitochondrial function.
HRV · Mitochondria
Patent 07 · Regenerative
Multi-Omics Convergence Model for Systems Biology Diagnosis
Framework for integrating genomics, transcriptomics, proteomics and metabolomics into a convergent biological constraint profile in accordance with GCR.
Multi-omics · GCR
Patented Formulation · Longevity
NMN+5™
Standard NMN raises NAD+ but depletes methyl groups — creating risk of homocysteine accumulation. NMN+5™ combines NMN with five synergistic cofactors (TMG, L-5-methylfolate, P5P, R5P, hydroxy/adenosyl-B12) to sustain methylation integrity simultaneously. NAD+ provides power. Methylation provides control. NMN+5™ provides both.
Cofactors
Trimethylglycine (TMG)
L-5-Methylfolate (B9)
Pyridoxal-5-phosphate (B6)
Riboflavin-5-phosphate (B2)
Hydroxy/Adenosyl-B12
Patent-protected formulation
Flagship

MediBalans BioAge™

Our most advanced diagnostic product — a multi-layer measurement of biological age at cellular, genetic and proteomic level.

Chronological age tells you nothing about how your body is actually ageing. MediBalans BioAge™ measures biological age on three levels: RNA transcriptome analysis (42,000 biomarkers), proteomic profile and patented translational gap analysis.

The result is a biological age score with specified deviation patterns — and a treatment plan designed to reduce the biological processes driving premature cellular ageing.

The test is performed in partnership with Dante Labs and their RNA transcriptome analysis platform. Clinical interpretation and protocol design is performed by Dr Mario Anthis personally.

Book
01
RNA Transcriptome Analysis
42,000 biomarkers for gene expression and longevity profile
Dante Labs
02
Proteomic Analysis
Protein production profile against a longevity reference panel
Proteomics
03
Translational Gap Analysis
Patented method for measuring gene→protein discrepancy
Patented
04
GCR Ageing Profile
Identification of primary biological ageing vector per GCR
GCR
05
Clinical Protocol
Personalised plan for biological age reduction
Treatment
I was 48 and wanted to know how my body was actually ageing — not what my passport says. The BioAge test gave me a biological age score and a concrete plan. Three months later I had measurable improvements across every marker.
Stefan W.  ★★★★★
BioAge™ · Longevity
Verified on Reco.se →
Partnerships

Kliniska samarbeten

MediBalans collaborates with leading diagnostic laboratories to ensure our diagnostics maintain scientific excellence.

Dante Labs
Multi-omics · Genomik · Transkriptomik
Official partnership for RNA transcriptome analysis and whole genome sequencing. Dante Labs' platform powers MediBalans BioAge™ at laboratory level — 42,000 biomarkers analysed according to validated longevity protocol.
RNA transcriptome analysis (42,000 markers)
Whole Genome Sequencing WGS 30x
Proteomic analysis
Genova Diagnostics
Functional diagnostics · Distributor
MediBalans is the exclusive Genova Diagnostics distributor in Sweden. Genova is a world-leading provider of functional diagnostic tests in gut health, hormones, nutritional status and metabolomics.
GI Effects® Comprehensive Stool Profile
DUTCH Complete hormone panel
NutrEval® metabolomics
Cell Science Systems
Immune reactivity · Distributor
Distributor of the ALCAT test in Sweden. Cell Science Systems are the creators of ALCAT — a test for delayed immune reactivity to foods, additives and chemicals, supported by a double-blind randomised controlled trial (Ali et al., BMJ Open Gastroenterology 2017).
ALCAT up to 250 foods, additives and chemicals
ALCAT chemicals & additives
ALCAT moulds & antibiotics
Cell Science Systems — CMA
Intracellular nutrition · CMA
Cellular Micronutrient Assay (CMA) from Cell Science Systems — an intracellular micronutrient test. Measures 55 micronutrients directly in white blood cells, showing functional cellular nutrient status rather than serum concentration.
CMA — 55 intracellular micronutrients
Antioxidant status and immune function
Applied Research

Research applied to you

Our research is not academic — it is applied directly in every patient encounter. Book a consultation to see how the GCR framework and our diagnostic portfolio can be applied to your situation.