What does the Menopause Plus test measure?

Menopause Plus™ measures sex hormones (oestradiol, oestrone, oestriol, progesterone, testosterone), oestrogen metabolism, melatonin and cortisol in saliva and urine. It is designed for peri- and post-menopausal women and provides a complete picture of the hormonal transition.

What is the difference between Menopause Plus and a standard hormone test?

Standard blood tests measure FSH and E2 — two markers. Menopause Plus measures 6 hormones, the P/E2 ratio, melatonin (for sleep disturbance) and cortisol (for the stress component of menopause). It also includes oestrogen metabolism, which is critical for assessing the risk profile of hormone therapy.

Can Menopause Plus help with sleep problems during menopause?

Yes. Menopause Plus includes a melatonin profile (measured at three time points) that identifies disrupted circadian rhythm — a common but frequently overlooked cause of sleep problems during menopause.

How much does Menopause Plus cost?

Menopause Plus™ is priced at SEK 9,300 at MediBalans, the official Swedish Genova distributor. Samples are collected at home (saliva and urine).

Genova Diagnostics · Official Swedish Distributor

Menopause Diagnostics · Saliva- and Urine-Based

Menopause Plus™
Complete picture of menopause.

Combines salivary sex hormones, estrogen metabolism and melatonin profile in one test. Designed specifically for peri- and post-menopausal women.

Order Menopause Plus™ — 9 300 kr

Test kit shipped to you. Includes 2 months access to meet mario.

Menopause Hot Flushes Sleep Problems Mood Swings Weight Gain Cardiovascular Risk

Saliva + UrineSample Type

6 Hormones + MelatoninMarkers Measured

Home TestKit Shipped to You

14–21Day Turnaround

Clinical Domains & Sample Report

What Menopause Plus™ measures

01 Sex Hormones — estradiol, estrone, estriol, progesterone, testosterone

02 P/E2 Ratio — progesterone's protective balance against estrogen

03 Melatonin — circadian rhythm and sleep quality

04 Cortisol — stress hormone pattern and adrenal function

05 DHEA — adrenal reserve and vitality marker

Estrogen Metabolites

Menopause Plus also includes urinary estrogen metabolites that reveal whether estrogen is broken down via the protective 2-OH pathway or via the harmful 4-OH or 16-OH pathway. This information is critical for risk assessment and treatment decisions.

View sample report (PDF)

Global Constraint Rule

Hormonal diagnostics in clinical context

Dr Mario Anthis interprets Menopause Plus within the MediBalans GCR (Global Constraint Rule) framework — a diagnostic hierarchical system that evaluates hormonal patterns in the context of nutrition, gut function and genetic methylation capacity.

The test maps the hormonal landscape so that treatment can address root causes rather than suppress symptoms. The estrogen pathways revealed in Menopause Plus determine whether the patient requires methylation correction, dietary recommendations or specific hormonal support.

GCR — The role of hormone metabolism in the constraint hierarchy

Elevated 4-OH estrogen metabolites in Menopause Plus signal increased oxidative burden and potentially genotoxic risk. This information is combined with CYP1B1 and COMT genetics (WGS) and intracellular methylation capacity (CMA) to establish the primary constraint.

GCR Protocol · Three Diagnostic Layers

Menopause Plus is always interpreted in the context of CMA and WGS

CMA intracellular nutritional analysis confirms whether the cofactors required for hormone metabolism — B6, magnesium, zinc — are actually available inside the cells to drive the 2-OH pathway.

Menopause Plus maps sex hormones, estrogen metabolism, melatonin and cortisol in a comprehensive test. Provides the functional picture of hormonal balance and metabolism pathways.

WGS genome analysis reveals genetic variants in CYP1B1, COMT and MTHFR that affect estrogen metabolism and methylation. Provides the genetic framework behind Menopause Plus findings.

"I had hot flushes every night for two years and slept no more than four hours. Menopause Plus showed my estrogen was breaking down via the 4-OH pathway — the harmful pathway — and that progesterone was critically low. With targeted treatment the flushes disappeared within six weeks."

Karin S. Perimenopause · Sleep Disturbances · 2 years · Verified on Reco.se

Frequently asked questions

Questions about Menopause Plus

Menopause Plus measures salivary sex hormones (estradiol, estrone, estriol, progesterone, testosterone), DHEA and cortisol at four points during the day, melatonin, and urinary estrogen metabolites. It provides a comprehensive picture of hormonal balance, stress response and estrogen metabolism in a single test.

Menopause Plus is indicated in perimenopause, menopause and post-menopause — particularly for hot flushes, sleep disturbances, mood swings, weight gain and reduced libido. It is also indicated when investigating or monitoring hormone replacement therapy (HRT).

Standard hormone tests measure blood levels at a single point and miss diurnal variation, estrogen fractions and metabolism pathways. Menopause Plus measures bioactive hormones in saliva at four time points, melatonin for sleep quality, and estrogen metabolites revealing whether estrogen is broken down via protective or harmful pathways.

Menopause Plus uses saliva samples (four times during the day) and a first morning urine sample. The kit is shipped to your address with detailed instructions. The sample is sent directly to Genova's laboratory with the included prepaid return envelope.

Related tests

Often combined with Menopause Plus

Estrogen Metabolism · Genova

Essential Estrogens™ FMV

Essential Estrogens FMV measures exactly how estrogen is metabolised — via the 2-OH (protective), 4-OH (harmful) or 16-OH pathway. Recommended as a complement for a detailed metabolism profile.

Intracellular · Cell Science Systems

CMA — Cellular Micronutrient Analysis

CMA confirms whether the cofactors required for hormone metabolism — B6, magnesium, zinc — are actually available inside the cells.

Genomic · Whole Genome Sequencing

WGS (Whole Genome Sequencing)

Genetic variants in CYP1B1, COMT and MTHFR affect estrogen metabolism and methylation. WGS provides the genetic framework behind Menopause Plus findings.

What makes Menopause Plus™ more complete than other menopause tests?

A fact-based comparison.

	MediBalans / Menopause Plus™	GetTested / Menopause test	Werlabs / Menopause test	Medisera / Menopause test
Sex hormones (E1, E2, E3, P4, T)	✓ (saliva)	FSH rapid test (urine)	E2 + FSH (blood)	E2 + FSH + AMH (blood)
Melatonin (3 data points)	✓	—	—	—
Cortisol	✓	—	—	—
DHEA	✓	—	—	—
Oestrogen metabolism	✓	—	—	—
P/E2 ratio	✓	—	—	—
Therapeutic reference ranges	✓ (bioidentical HRT cohort)	—	—	—
Physician interpretation	✓ Always included	—	Physician comment	Physician comment
Price	SEK 9,300	~SEK 200 (rapid test)	~SEK 800	~SEK 1,200

A FSH rapid test confirms you are in menopause. Menopause Plus™ tells you why you feel the way you do — and what can be done about it.

Next step

Map your hormonal balance
through menopause.

Menopause Plus is interpreted by Dr Mario Anthis in the context of your CMA and WGS findings. Book a consultation to determine which combination of tests is indicated for your specific presentation.

Order Menopause Plus™ — 9 300 kr Book Consultation