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Genova Diagnostics · Exclusive distributor in Sweden
Estrogen Metabolism · Urine-Based (FMV)

Essential Estrogens™
How your estrogen breaks down.

Reports selected oestrogens, urinary metabolites and calculated ratios from a first-morning urine sample collected at home.

Order Essential Estrogens™ — 6 800 kr

Direct purchase: kit, Genova laboratory analysis and laboratory report included. No mandatory consultation. Medical interpretation and treatment are optional and separate.

First-morning urineHome collectionLaboratory reportOptional medical review
UrineSpecimen (FMV)
8Estrogen metabolites
HomeCollection — kit shipped
14–21Days turnaround
Understanding the report

Measured metabolites and limitations

Blood and urine are different sample matrices. Essential Estrogens reports selected urinary oestrogens, metabolites and calculated relationships; it does not replace clinically indicated blood tests or medical assessment.

The laboratory report does not on its own label pathways as clinically “protective” or “harmful,” quantify cancer risk, establish a diagnosis or determine treatment.

GCR — Estrogen metabolism in the constraint hierarchy

Genetic variants and urinary metabolites require careful interpretation. Do not start or change hormone treatment, supplements or medication based only on a self-ordered report.

GCR Protocol · Three diagnostic layers

Clinical review is optional and separate

1
Genetic testing is a separate service. Selected variants may add context, but the urine report does not confirm whether a genetic variant is functionally expressed or quantify disease risk.
2
Essential Estrogens FMV reports selected oestrogens, urinary metabolites and calculated relationships. It does not classify metabolism as protective or risk-increasing by itself.
3
CMA intracellular nutrient analysis confirms whether the cofactors required for phase 2 detoxification — magnesium, B6, folate — are present inside the cells. COMT is magnesium-dependent — magnesium deficiency directly impairs catecholestrogen detoxification.
What It Measures

Five clinical measurement domains

Domain 01 · Estrogens

Estrogen Profile

Estrone (E1), estradiol (E2) and estriol (E3) are measured in urine via fasted morning void sample. Provides the complete estrogen profile in functional context rather than as a snapshot value in serum.

Domain 02 · 2-OH Metabolites

2-OH Metabolites

The report presents selected 2-hydroxylated oestrogen metabolites. These values do not independently quantify cancer risk or determine treatment.

Domain 03 · Risk Metabolites

4-OH Metabolites

The report presents selected 4-hydroxylated oestrogen metabolites. A result should not be labelled clinically harmful from the value alone and is not a cancer-risk calculation.

Domain 04 · Estrogenic Activity

16-OH Metabolites

16-alpha-hydroxy-estrone is a potently estrogenic metabolite. Elevated 16-OH production is associated with increased proliferative signalling in estrogen-receptor-positive tissue — breast, endometrium, cervix.

Domain 05 · Methylation

Methylation Activity

2-methoxyestrone and 4-methoxyestrone are measured as indicators of COMT enzyme function. These methylated metabolites are inactive and safe. The methylated/unmethylated ratio confirms COMT activity's actual clinical expression.

Sample Report

What your results look like

The Essential Estrogens report shows the eight estrogen metabolites with clinical ratio calculations — the 2-OH/16-OH ratio, methylation index and catabolic/anabolic estrogen balance.

Essential Estrogens sample report — estrogen metabolism map and steroidogenic pathways

Five clinical domains

  • 01 Estrogens — estrone (E1), estradiol (E2), estriol (E3)
  • 02 2-OH Metabolites — measured values and relationships
  • 03 4-OH Metabolites — measured values and relationships
  • 04 16-OH Metabolites — measured values and relationships
  • 05 Methylation Activity — COMT enzyme function and phase 2 detoxification
View full sample report (PDF) →
Optional clinic route

If you later choose MediBalans care

The steps below describe a separate clinical service, not what is included in the SEK 6,800 direct test price.

01
Optional Clinical Consultation
A separately booked medical review may consider whether the report is relevant to your history and whether standard hormone, cancer-risk or other assessment is needed. No family history or symptom automatically makes this test appropriate.
GCR AssessmentClinical History
02
Sample Collection & Laboratory Analysis
The kit is shipped to your home. First-morning urine is collected according to the kit instructions. Return handling is confirmed in the order and kit information. Turnaround is listed as 14–21 days from laboratory receipt.
Home CollectionFMV UrineCLIA-Certified
03
Optional Medical Interpretation
If booked, a clinician reviews the report alongside history, medication and other relevant findings. Additional tests are considered only if clinically justified and separately agreed.
Multi-Layer AnalysisGCR HierarchyPrioritisation
04
Separate Care Plan, If Indicated
Any diagnosis, supplement recommendation, hormone treatment or follow-up plan requires a medical assessment and is not included in the test purchase.
Targeted Treatment6 MonthsFollow-Up
Why MediBalans

What sets us apart

01

Estrogen metabolism is never interpreted in isolation

A separate MediBalans review may consider the report alongside history, standard care and other relevant findings. Genetic and CMA testing are not included, are not automatically required and do not turn the urine profile into an individual risk calculation.

02

Exclusive Genova Distributor

MediBalans is the exclusive Genova Diagnostics distributor in Sweden with a direct laboratory relationship and full access to all Genova panels.

03

We sell no supplements

MediBalans sells no supplements. All recommendations — DIM, magnesium, methylfolate — are based exclusively on what the metabolite measurements and genomic data show.

FAQ

Questions about Essential Estrogens

Essential Estrogens measures the eight primary estrogen metabolites in urine — estrone (E1), estradiol (E2), estriol (E3) and their hydroxylated breakdown products via the 2-OH, 4-OH and 16-OH pathways. FMV (Fasted Morning Void) is the preferred collection method for hormone metabolites as it reflects the body's detoxification activity overnight without dietary interference.

The report lists selected 2-OH, 4-OH and 16-OH metabolites and calculated relationships. Their meaning depends on the assay, reference information and clinical context. The report does not on its own quantify cancer risk.

The methylation index measures the actual activity of the COMT enzyme — how efficiently catecholestrogens are methylated to inactive methoxy forms. An impaired methylation index indicates that 4-OH metabolites are not being detoxified quickly enough, increasing the risk of DNA adduct formation. COMT is magnesium-dependent — magnesium deficiency, which is common and invisible in standard tests, directly impairs COMT activity.

Yes. Order directly for SEK 6,800. The price includes the kit, Genova laboratory analysis and laboratory report. Medical interpretation and treatment are optional and separate.

Related Tests

Often combined with Essential Estrogens

Complete Hormone Panel · Genova

Women's Health Plus+ — Complete Hormone Panel

Women's Health Plus+ includes estrogen metabolism, sex hormones, cortisol, DHEA and melatonin in a comprehensive panel. Recommended for complete hormonal picture.
Genomic · Genova

MethylDetox — 38 Methylation Genes

MethylDetox reveals CYP1B1 and COMT variants that govern estrogen hydroxylation and detoxification. Provides the genetic framework for Essential Estrogens interpretation.
Intracellular · Cell Science Systems

CMA — Cellular Micronutrient Analysis

CMA is a separate assay using a different sample and method. It does not automatically validate an oestrogen-metabolite result or provide cause and remedy.

How does Essential Estrogens™ differ from serum oestrogen tests?

A fact-based comparison.

MediBalans / Essential Estrogens™ GetTested Werlabs / Oestrogen Standard blood test
Measures oestrogen metabolism✓ (8 metabolites)———
2-OH metabolites✓———
4-OH metabolites✓———
16-OH metabolites✓———
COMT methylation activity✓———
2/16 relationship reported✓Check seller——
Oestrogen levels (E1, E2, E3)✓—✓✓ (E2)
LaboratoryGenova, CLIA-cert., USA—KarolinskaRegional lab
Medical interpretationOptional, booked separatelyCheck sellerCheck providerVia referral
PriceSEK 6,800Not available~SEK 500SEK 0–200

The products use different sample matrices and report scopes. Third-party offerings and prices can change; verify current details before comparing or ordering.

Direct order

Map your
estrogen metabolism.

SEK 6,800 includes the kit, laboratory analysis and laboratory report. No consultation is required. Optional medical interpretation can be booked separately after the report is ready.

Order Essential Estrogens™ — 6 800 kr Book

Direct order and MediBalans clinical care are separate services.

Keep reading. All 47 articles — symptom guides, clinical notes, investigations and diagnostics — are collected and searchable in the knowledge base.

Go to the knowledge base →

One complimentary month included

Explore your Genova report with Meet Mario

Every Genova test ordered through MediBalans includes one complimentary month of Meet Mario access. Use it to explore the report, receive contextual explanations and collect questions about the results.

Digital support is not a medical assessment. The test purchase does not create a MediBalans patient relationship; clinical interpretation, treatment and follow-up are separate services.

See what Meet Mario can help with
Meet Mario view for exploring a laboratory report